IONTAS’ management have published high impact research papers on many core technology advances in antibody drug discovery.

40 Results Found

A comprehensive search of functional sequence space using large mammalian display libraries created by gene editing

Publication: mAbs. June 2019. doi:10.1080/19420862.2019.1618673 PMID: 31107136.

Authors: Parthiban K, Perera RL, Sattar M, Huang Y, Masters E, Griffiths D, Surade S, Leah R, Dyson M, McCafferty J

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Targeting early changes in the synovial microenvironment: a new class of immunomodulatory therapy?

Publication: BMJ Journals. December 2018, 78 (2). doi:10.1136/annrheumdis-2018-214294 PMID: 30552174.

Authors: Susan R Aungier, Alison J Cartwright, Anja Schwenzer, Jennifer L Marshall , Michael R Dyson, Peter Slavny, Kothai Parthiban, Aneesh Karatt Vellatt, Ilfita Sahbudin, Eric Culbert, Patrick Hextall, Felix IL Clanchy, Richard Williams, Brian D Marsden, Karim Raza, Andrew Filer, Christopher Dominic Buckley, John McCafferty, Kim S Midwood

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In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies

Publication: Nature Communications. October 2018. doi:10.1038/s41467-018-06086-4 PMID: 30279409.

Authors: Laustsen AH, Karatt-Vellatt A, Masters EW, Arias AS, Pus U, Knudsen C, Oscoz S, Slavny P, Griffiths DT, Luther AM, Leah RA, Lindholm M, Lomonte B, Gutiérrez JM, McCafferty J

Basics of Antibody Phage Display Technology

Publication: Toxins (Basel). June 2018. doi:10.3390/toxins10060236 PMID: 29890762.

Authors: Ledsgaard L, Kilstrup M, Karatt-Vellatt A, McCafferty J, Laustsen AH

Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from ligand binding domain

Publication: Scientific Reports. August 2017. PMID: 28827556.

Authors: DiCara DM, Chirgadze DY, Pope AR, Karatt-Vellat A, Winter A, Slavny P, van den Heuvel J, Parthiban K, Holland J, Packman LC, Birchmeier W, Gherardi E, McCafferty J