Latest Publication Mammalian Display

Posted 28 October 2020

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We are delighted to announce today the publication of our latest Mammalian Display publication entitled "Beyond affinity: selection of antibody variants with optimal biophysical properties and reduced immunogenicity from mammalian display libraries”:

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IONTAS’s proprietary Mammalian Display system has already been shown to enable screening of 10’s millions of antibody variants based on binding characteristics. As more antibody therapeutics pass through the drug development pipeline it is clear that “developability” problems due to non-optimal biophysical properties can arise leading to delay or failure in traversing the development process. In this paper we show that our proprietary Mammalian Display system also helps to address developability issues during the earliest stages of lead discovery, thereby significantly de-risking the future development of antibody drugs.