Discovery on Target 2019

16-19 September 2019

Boston, MA

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Dr Aneesh Karatt-Vellatt will be speaking at the Discovery on Target conference held in Boston (MA) from the 16th to 19th September.

More about the talk:

Title: Generation and Optimization of Antibody-like Modulators of Ion Channels by Fusing Venom Derived Miniproteins into Peripheral CDR Loops

Venom derived cysteine-rich mini proteins (knottins) have potential as therapeutic agents to block ion channels involved in cancer, autoimmunity and pain but suffer from manufacturing difficulties, short half-lives and a lack of specificity. Using the KnotBody technology, IONTAS have developed antibody-like inhibitors of multiple ion channels by fusing venom derived knottins into peripheral CDR loops. The “developability” profiles of these KnotBody molecules were further optimized by using the proprietary Mammalian Display technology.